The Best Estrogen Blockers for Men: How Aromatase Inhibitors Work

Aromatase inhibitors lower estrogen levels in the body by blocking aromatase, an enzyme that converts other hormones into estrogen. This slows or stops the growth of the tumor by preventing the cancer cells from getting the hormones they need to grow. https://canadaincome.ca/parabolan-steroid-course-everything-you-need-to/ Aromatase inhibitors are a hormone therapy (also called endocrine therapy).

Cancer

Although the FDA has not yet approved aromatase inhibitors for any of these purposes, many believe that supporting research will one day broaden the current treatment recommendations. Aromatase inhibitors should not be used in people with a known hypersensitivity to any of the active or inactive ingredients in the drug. With that being said, a drug allergy is not common with aromatase inhibitors, affecting less than one out of 10,000 users. Aromatase inhibitors work by binding to aromatase and preventing aromatization from occurring. By doing so, the production of estrogen may be reduced by as much as 95% in postmenopausal women. We talked with Layman to learn more about these hormone therapy drugs, which are available only to women who’ve completed menopause.

The Best Estrogen Blockers for Men: How Aromatase Inhibitors Work

Unliketamoxifen and raloxifene, AIs tend to speed up bone thinning, which can lead to osteoporosis. People with osteoporosis are more likely to have broken bones. Because of this, doctors often recommend checking bone density before starting one of these drugs. Women who haven’t gone through menopause, either naturally or as a result of cancer treatment, can have treatment to stop their ovaries from producing hormones.

• The heightened gonadotropin levels also upregulate the aromatase promoter, increasing aromatase production in the setting of increased androgen substrate.
• They will weigh up the benefit of taking the drug for longer with other factors, such as any side effects you have and whether you want to have children.
• Hormone therapy following surgery, radiation or chemotherapy has been shown to reduce the risk of breast cancer recurrence in people with early-stage hormone-sensitive breast cancers.
• This keeps estrogen levels down and helps prevent cancer cells from getting the estrogen they can use to grow and spread.
• You may have it if tamoxifen or aromatase inhibitors are no longer controlling your cancer.

In clinical settings, aromatase inhibitors are often used for treating the early stages of breast cancer in women and gynecomastia in men. There are quite a few pharmaceutical aromatase inhibitors on the market, namely Arimidex (anastrozole), Aromasin (exemestane), Nolvadex (tamoxifen), and Femara (letrozole). These drugs are non-steroidal compounds that strongly blunt the aromatization of androgens. They can drastically reduce estrogen levels in a short amount of time, so you should only use them under medical supervision. Fulvestrant is a type of hormone therapy for post menopausal women with secondary breast cancer that is hormone receptor positive .

Estrogen Blockers for Men: Everything You Need to Know

In doing so, the drugs lower the amount of estrogen in the body by as much as 95%. Aromatase inhibitors are among the most effective medications today for treating or preventing the recurrence of estrogen-fueled breast cancers in post-menopausal women. These medicines can reduce the risk of cancer recurrence in those who have been treated for early-stage breast cancer. Aromatase inhibitors also can be used to treat advanced breast cancer.